The Antidepressant Effect of Fluoxetine and Mozart K448 Combination Therapy on Hippocampal Serotonin and BDNF Levels

Despite the use of fluoxetine as a first-line therapy, some patients do not show good therapeutic effect. Effective antidepressant therapy will reverse low serotonin and BDNF levels found in depression. Mozart K. 448 was reported to yield effect for Based on findings, combination depression is very rare. Therefore, this study aimed determine combined hippocampal an animal model under CUMS conditions. In study, administered three different treatments, i.e. fluoxetine, Mozart, or fluoxetine-Mozart respectively. Hippocampal were assessed after 21 days treatment. Statistical analysis then carried out using T-test Mann-Whitney test ANOVA Kruskal-Wallis. The group has higher levels, but lower compared other groups with values 1,694±0.215 44,533±3,275,